Carefree and desperate to avoid any responsibility, Jessica, a college student, visits a yard sale to buy a gift for her best friend. However, the music box she brings home is haunted by a vicious demonic entity eager to feed off the lives of all who hear the box’s melody. After her best friend takes her own life, Jessica seeks the aid of two ghost hunters, but they too find themselves out of their depth. Desperate to free herself of the cursed box, she searches for the box’s origin only to find that true evil begins with best of intentions.
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Within the decadent walls of the Frankenstein mansion, the Baron and his depraved assistant Otto have discovered the means of creating new life. As the Baron’s laboratory begins to fill up with stitched body parts, the Baroness dallies with the randy new manservant and soon the decadent, permissive household is consumed by an outrageous, bizarre, and hilarious orgy of death and dismemberment.
The photographer Leon lives with his girlfriend and waitress Maya waiting for a chance to get in the photo business. When Maya contacts their friend Jurgis, he schedules a meeting for Leon with the successful owner of arts gallery Susan Hoff; she analyzes Leon’s work and asks him to improve the quality of his photos. During the night, the upset Leon decides to wander on the streets taking pictures with his camera, and he follows three punks down to the subway station; when the gang attacks a young woman, Leon defends her and the guys move on. On the next morning, Leon discovers that the woman is missing. He goes to the police station, but Detective Lynn Hadley does not give much attention to him and discredits his statement. Leon becomes obsessed to find what happened with the stranger and he watches the subway station. When he sees the elegant butcher Mahogany in the train, Leon believes he might be a murderer and stalks him everywhere, in the beginning of his journey to the darkness.
Grace Rhodes, who is studying to be a doctor, returns to her hometown as a strange illness is afflicting the local children. The symptoms include a high fever and spasms, but even weirder is what happens the next day: All those with the illness claim they are somebody else — then they begin murdering the grown-ups. After her sister undergoes the same sinister metamorphosis, Grace comes to believe there is some connection to an evil cult figure who may be returning from the grave.