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Jamie is a boorish, insensitive American twentysomething traveling in Chile, who somehow manages to create chaos at every turn. He and his friends are planning on taking a road trip north to experience a legendary shamanistic hallucinogen called the San Pedro cactus. In a fit of drunkenness at a wild party, Jamie invites an eccentric woman—a radical spirit named Crystal Fairy—to come along.
The son of an atheist, authoritarian father, believed to be liberal, wants to become a priest.
A girl who half-heartedly tries to be part of the “in crowd” of her school meets a rebel who teaches her a more devious way to play social politics; killing the popular kids.
When David is left by his fiancé just days before the wedding, Flula, his relentlessly upbeat best man, insists that the pair go on David’s previously planned honeymoon: a seven-day backpacking trip through the breathtaking mountains of Oregon. Their adventures are bookended with passages from William Clark’s diary describing his friendship with Meriwether Lewis and the terrain they crossed during their expedition.